All of the following statements about natriuretic peptides are true EXCEPT

A. Circulating levels of both atrial natriuretic peptide and brain natriuretic peptide (BNP) are elevated in patients with heart failure beach wedding wears suitable for mother of the bride

B. Plasma BNP level is useful in distinguishing cardiac from noncardiac causes of dyspnea in the emergency department setting

C. Elevated plasma BNP levels predict adverse outcomes in patients with acute coronary syndromes

D. Prohormone BNP is cleaved into the biologically inactive N-terminal (NT) proBNP and biologically active BNP

E. Circulating levels of NT-proBNP levels decrease with age